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Inhibitor of ACVR1 showed similar protective effects as miR-193a-5p. While overexpression of ACVR1 could attenuate protective effects of miR-193a-5p. To sum up, these findings suggest that circulating exosomes could shuttle between cells through dynamin and deliver miR-193a-5p to protect endothelial cells from oxidative stress damage via ACVR1.Coherent manipulation of light-matter interactions is pivotal to the advancement of nanophotonics. Conventionally, the non-resonant optical Stark effect is harnessed for band engineering by intens