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In conclusion, WXFL-152, which is currently in phase Ib clinical trials, is a novel and effective triple-angiokinase inhibitor with clear PD and PK in tumor therapy.The behavioral responses exerted by spinal administration of the opioid-neurotensin hybrid peptide, PK23, were studied in adult male rats. The antinociceptive effect upon exposure to a thermal stimulus, as well as tolerance development, was assessed in an acute pain model. The PK23 chimera at a dose of 10 nmol/rat produced a potent pain-relieving effect, especia

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2 kcal/mol, which caused the cationic exchange resin to be easily destroyed. According to the characterization results, the characteristic intermediates were determined, indicating that desulfonation, valence change of nitrogen atom, and cleavage of long-chain carbon skeleton existed during the reaction, but incomplete oxidation still remained.Air pollution and meteorological factors can exacerbate susceptibility to respiratory viral infections. To establish appropriate prevention and intervention strategies, it is important to determine