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In addition, fluoxetine 50 μM use-dependently inhibited Kv2.1 currents at different frequencies. In conclusion, the inhibition of Kv2.1 by fluoxetine was concentration-dependent, voltage-dependent and use-dependent. The accelerated steady-state inactivation of Kv2.1 channels induced by fluoxetine might be ascribed to the delay of the recovery process of Kv2.1. V.PURPOSE Stereotactic body radiation therapy is a therapeutic option offered to high surgical risk cancer patients with lung cancer. Focal lung irradiation in mice is a new prec
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