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First Line Treatment For ADHD in Adults Certain people suffering from ADHD find that medications help to manage their symptoms. The stimulants like methylphenidate or amphetamine work by increasing brain activity in areas that regulate attention and behavior. , such as the non-stimulant drug atomoxetine and antidepressants that work differently, yet are effective. Patients who are taking medication should visit their GP regularly to check for the body's reactions and adjust