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4%; 706/1048); most of these were managed in HIC (72.8%, P 0.01). The likelihood of receiving antifungals being in high-risk group was higher in HIC compared with LMIC (ratio of 5.8 vs. 3.4, P 0.01). Antifungal prophylaxis was more likely prescribed in HIC (67.2% vs. 30.4%, P 0.01). Fluconazole was the most frequently prescribed drug. The proportional use of fluconazole was higher in LMIC compared with HIC. A significant variability of antifungal prescribing patterns was observed. The proportional use of systemic antifun