https://www.selleckchem.com/pr....oducts/salinosporami
Western blot and immunostaining analyses of AV nodes showed that ZO-1 loss decreased connexin (Cx) 40 expression and intercalated disc localization. Consistent with the mouse model study, immunohistochemical staining showed that ZO-1 is abundantly expressed in the human AV node, and colocalizes with Cx40. Ventricular conduction was not altered despite decreased localization of ZO-1 and Cx43 at the ventricular intercalated disc and slightly decreased left ventricular ejection fraction, suggesting ZO-1 is diff