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The ROC curve showed that there may be good diagnostic value of serum circ_RUNX2 in OA. RUNX2-derived circ_RUNX2 may be involved in OA development via ECM-receptor interaction pathways and may be used as potential clinical indicator of OA. RUNX2-derived circ_RUNX2 may be involved in OA development via ECM-receptor interaction pathways and may be used as potential clinical indicator of OA.Strongly electric fish use gradients of ions within their bodies to generate stunning external electrical discharges; the most powerful of these organisms,