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3 ( 0.01). The serum IL-6 level was higher in ET patients with cognitive impairment compared with normal cognitive ability ( 0.01). ROC analysis showed that an IL-8 level of 4 pg/ml and higher related with a high risk of severe tremor in ET (AUC-ROC = 0.761). Our findings demonstrate that neuroinflammation makes a certain contribution to the development of ET. Our findings demonstrate that neuroinflammation makes a certain contribution to the development of ET.Regulation of stress reactivity is a fundamental priority of al