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For full-state constrained nonlinear systems with input saturation, this article studies the output-feedback tracking control under the condition that the states and external disturbances are both unmeasurable. A novel composite observer consisting of state observer and disturbance observer is designed to deal with the unmeasurable states and disturbances simultaneously. Distinct from the related literature, an auxiliary system with approximate coordinate transformation is used to attenuate the effects generated by input saturation. Th