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SBI was associated with a significant decrease in the frequency of heavy drinking and improvement in stages of motivation. SBI among patients with mood disorders had a small but significant effect on alcohol use. SBI among patients with mood disorders had a small but significant effect on alcohol use.Enzalutamide is an effective drug for the treatment of castration-resistant prostate cancer (CRPC), but acquired enzalutamide resistance is usually unavoidable within the short term in many patients. Lycopene, a safe and effectiv