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How Does Medication For ADHD Work? The stimulants are among the most commonly used ADHD medication prescribed. They work by increasing the levels of brain chemicals known as dopamine and norepinephrine. They include amphetamines, methylphenidate and dextroamphetamines (Adderall) and lisdexafetamine, (Vyvanse). These are often prescribed in long-release forms that last from up to eight hours or longer. This minimizes the ups and downs
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