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The thickness of laser-alloyed layers (308-432 μm) was significantly higher than that produced using diffusion boriding techniques.Background and Objectives Insulin resistance (IR) is a serious condition leading to development of diabetes and cardiovascular complications. Hyper-activation of cannabinoid receptors-1 (CB1) has been linked to the development of metabolic disorders such as IR. Therefore, the effect of blocking CB1 on the development of IR was investigated in the present study. Materials and Methods A 12-week high-fructose/h