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p62/SQSTM1 (hereafter as p62) is a stress-inducible cellular necessary protein, which interacts with various signaling proteins to regulate a number of cellular functions. Developing outlines of proof supported a critical part of p62 in tumorigenesis, and p62 can become a therapeutic target for cyst. In this review, we summarize biological features of architectural domain names of p62, reported bioactive particles targeting p62, therefore the commitment between p62 and tumo