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Increased mortality was also observed among KTRs with concomitant HIV infection (87.5% vs. 36.1%; p less then .01). Conversely, immunosuppression intensity and degree of reduction following COVID-19 diagnosis were not associated with either survival or acute allograft rejection. Our findings potentially support a strategy of individualization of immunosuppression targets based on patient-specific risk factors, rather than universal immunosuppression reduction for KTRs at risk from COVID-19.Brugada syndrome (BrS) is a sudden cardiac death