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We used the inverse-variance weighted means for causal impact estimation and weighted median, maximum possibility, and MR Egger regression options for sensitivity analyses. This paper aimed to identify white matter (WM) and grey matter (GM) abnormalities in an example of early PD patients, and their particular correlations with motor and non-motor symptom severity. We enrolled 62 de novo PD clients and 31 healthier topics. Disease seriousness and non-motor symptom burden were evaluate