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the anti-inflammatory cytokine TGF-β, which indicates an acquisition of M2-like macrophages characteristics. Copyright © 2020 Varela, Marlinghaus, Sartori, Viebahn, Salber and Ciardelli.Background Endoscopic endonasal transsphenoidal surgery (EETS) is a standard technique used to approach sellar tumors. It is relatively safe, minimally invasive and carries a low risk of complications. However, one of the common complications reported with this technique is CSF leakage which causes morbidity, an increase in recovery time and hospital