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But, its biological functions and underlying molecular mechanisms in pancreatic cancer tumors are mainly unidentified. The goal of this study was to explore the role of lncRNA OIP5-AS1 in pancreatic cancer. Quantitative real time PCR analysis uncovered that OIP5-AS1 is highly expressed in pancreatic cancer tissues versus adjacent non-tumor areas. In vitro functional assays indicated that downregulation of OIP5-AS1 or overexpression of miR-342-3p inhibited the proliferation, reduc