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ies in lower- and middle-income countries to explore its causes so that targeted strategies can be developed to address this issue. University students are at significantly higher risk of serogroup B meningococcal (Men infection, which can result in debilitating sequelae and excessive healthcare usage. This study aimed to elucidate the impact of universal pre-enrollment vaccination on MenB outbreak probability and the cost-effectiveness in outbreak-only scenarios. We developed an infectious disease transmission model to determine the