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21, p=0.045), in the WISC-IV, at age 7years. Parental concern was more common in the group that used 50 words or fewer (Mann-Whitney U test, p=0.011). This easily accessible measure of number of words seems to be a valuable marker for intellectual functioning later in life. This easily accessible measure of number of words seems to be a valuable marker for intellectual functioning later in life.This study aims to investigate the protective effect of roflumilast, a phosphodiesterase (PDE)-4 enzyme inhibitor, and demonstrate its possible