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Purpose Next-generation sequencing (NGS) has become more accessible, leading to an increasing number of genetic studies of familial bradycardia being reported. However, most of the variants lack full evaluation. The relationship between genetic factors and bradycardia should be summarized and reevaluated. Methods We summarized genetic studies published in the PubMed database from 2008/1/1 to 2019/9/1 and used the ACMG/AMP classification framework to analyze related sequence variants. Results We identified 88 articles, 99 sequence varian

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04), and LOS was 13h shorter (p = 0.02) on average. Pain scores at all study timepoints and patient satisfaction at 6weeks were similar (p  0.05). At 24 h postoperatively, PAP levels were 537.53 ± 94.1µg/L vs. 464.39 ± 114.6µg/L (p = 0.05), and Il-6 levels were 40.94 ± 26.1pg/mL vs. 60.51 ± 33.0pg/mL (p = 0.03), in DAA vs. PLA, respectively. In the immediate postoperative period, DAA patients were ready for discharge before PLA patients. DAA patients had shorter LOS, a lower inflammatory response, and higher systemic markers o