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Studies on the association of oral contraceptive (OC) use and pancreatic cancer showed inconsistent findings. To evaluate the relationship between OC use and pancreatic cancer risk. A literature search for observational studies (case-control and cohort studies) was conducted up to December 2020. A meta-analysis was performed by calculating pooled relative risks (RRs) and 95% confidence intervals (CIs). Heterogeneity was assessed using Cochran's chi-square test and statistic. Subgroup analyses were performed by study design, source of c