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VSMC proliferation was analysed using Cell Counting Kit-8 (CCK-8) and EdU assays, while migration had been considered by Transwell assay. Mechanistically, the direct binding between two proteins ended up being validated by immunoprecipitation. We discovered that ARC expression was stimulated in VSMCs during cell proliferation. Our results additionally revealed that ARC presented cellular proliferation and induced phenotypic modulation of VSMCs in vitro and vivo. Mechanistic studies demon