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ADHD OTC Medication The majority of adults and children who are taking ADHD medications will have side effects. These usually include loss of appetite, upset stomach and changes in heart rate. A healthy diet and sufficient sleep can reduce these side effects. Stimulant drugs increase the signaling between brain cells, which helps kids control their impulses and concentrate. They can also trigger tics or increase blood pressure. These drugs are controlled substances that can be crushed or inhaled to