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Nanoparticles with diverse structures and unique properties have attracted increasing attention for their widespread applications. Co-precipitation under rapid mixing is an effective method to obtained biocompatible nanoparticles and diverse particle carriers are achieved by controlled phase separation via interfacial tensions. In this Minireview, we summarize the underlying mechanism of co-precipitation and show that rapid mixing is important to ensure co-precipitation. In the binary polymer system, the particles can form four differe