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Atopic dermatitis (AD) is a multifactorial, heterogeneous condition associated with epidermal barrier disturbance and intense systemic inflammation. Formerly, we indicated that exosomes derived from person adipose tissue-derived mesenchymal stem cells (ASC-exosomes) attenuate AD-like signs by lowering several inflammatory cytokine levels. Here, we investigated ASC-exosomes' impacts on skin barrier renovation by examining protein and lipid items. We found that subcutaneous injection of