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05). Conclusions The short-term efficacy of spinal endoscopic surgery and ACDF was equal in the treatment of CSM. The spinal endoscopic surgery was significantly superior to ACDF in reducing the operation time, the intraoperative blood loss and the hospitalization stay. 2020 Journal of Spine Surgery. All rights reserved.Background Anterior endoscopic cervical decompression with discectomy and foraminotomy is an alternative to open surgical treatment of unrelenting cervical radiculopathy (CR) in patients who have failed non-operativ

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The main phase-I enzymes involved in metabolism of POD in vitro include CYP2C9, CYP2C19, CYP3A4, and CYP3A5.POD administration to mice caused hepatic and intestinal toxicity, and the cellular damage was exacerbated when 1-aminobenzotriazole, a broad-spectrum inhibitor of CYPs, was administered with POD, indicating that POD, but not its metabolites, induced hepatic and intestinal toxicities.This study elucidated the metabolic map and provides important reference basis for the safety evaluation and rational for the clinical application of POD.The pres