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In contrast, with respect to food intake, resistin has weaker effects, but in regard to insulin secretion and thermogenesis, leptin and resistin have opposing actions. Thus, in conditions in which there is increased resistin and leptin levels, the result of crosstalk in the central nervous system could contribute to worse cardiovascular and metabolic complications. Screening the general public for atrial fibrillation (AF) may enable early detection and timely intervention, which could potentially decrease the incidence of stroke. Existing