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We also identify a unique protospacer adjacent motif (PAM) that facilitates site-specific cleavage of the NRF2 gene present only in tumor genomes. Implications Our results begin to set a scientifically meritorious foundation for the exploitation of CRISPR-directed gene editing as an augmentative therapy for lung cancer and other solid tumors. Copyright ©2020, American Association for Cancer Research.BACKGROUND Type 2 diabetes mellitus (T2DM) is a demanding condition that impacts the person living with the condition physically and psycho
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