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amme and will be published in full in ; Vol. 24, No. 56. See the NIHR Journals Library website for further project information. This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 24, No. 56. See the NIHR Journals Library website for further project information. Increased life expectancy leads to older and frailer surgical patients. Co-management between medical and surgicalspecialities has proven favourable in complex situatio

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The reliable end points, appropriate for use in regulatory risk assessment are presented.The Panel on Food Additives and Flavourings added to food (FAF) provided a scientific opinion re-evaluating the safety of hydrogenated poly-1-decene (E 907) when used as a food additive. Hydrogenated poly-1-decene (E 907) is authorised as a food additive in the EU in accordance with Annex II to Regulation (EC) No 1333/2008. Hydrogenated poly-1-decene is of low acute toxicity and does not raise concern for genotoxicity. Toxicity and carcinogenicit