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erall survival (OS) data and quality of life assessment are collected to determine whether the primary aim of 6 months OS benefit with preserved quality of life will be met. This will support evidence-based decision making in multidisciplinary colorectal cancer care and can be readily implemented in daily practice.In the last decade, multi-catalysis has emerged as an excellent alternative to classical methods, rapidly elaborating complex organic molecules while considerably decreasing steps and waste generation. In order to further d