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These predictors are used to construct a nomogram. C index is 0.81 (95% confidence interval0.79-0.83). The combination of the calibration curve and ROC curve indicates that the model has high discriminability. The decision curve shows benefits in clinical practice when the threshold probability is 6% and 58%, respectively. The internal verification results using Harrell's C-Index were 0.80 (95% confidence interval 0.78-0.83). Combining information such as age, sex, barbeque, smoking, passive smoking, type of energy, ventilation

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Inflammasomes are crucial for innate immunity against infections and, when deregulated, also contribute to inflammatory diseases. Here, we identify a critical function of the E3 ubiquitin ligase Peli1 in regulating the activation of NLRP3 inflammasome. Peli1 deficiency impairs induction of interleukin-1β (IL-1β) secretion by different NLRP3 inducers, but not by inducers of the Aim2, NLRP1, and NLRC4 inflammasomes. Peli1-deficient mice have alleviated peritonitis induction by alum and display increased resistance to lipopolysaccharid