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The smaller the sample size, the more the predictor-risk relation depended on the modeling algorithm used, and also sampling variability played an increased role. Predictive performance was similar if the models were derived on the full data set, whereas smaller sample sizes favored simpler models. Predictor-risk relations from ML models may differ from those obtained by statistical models, even with large sample sizes. Hence, predictors may assume different roles in risk prediction models. As long as sample size is sufficient, predictiv