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001) increased compared to baseline. Patients without POR showed a decrease of Streptococcaceae (FDR=0.003) and Actinomycineae (FDR=0.06). The mucosa-associated microbiota profile had good discriminative power to predict POR, and was superior to clinical risk factors. At month 6, patients experiencing POR had a higher abundance of taxa belonging to Negativicutes (FDR=0.04) and Fusobacteria (FDR=0.04) compared to patients without POR. CONCLUSIONS Microbiota recolonization after ileocecal resection is different between recurrence and non-r