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This document provides guidance, history, and tips about how to recognize quality tests and centers around assessing the substance, value, and relevance of clinical test outcomes. This document replaces the document of the same title, last published in 2008 (Fertil Steril® 2008;90S114-2. Scientific research making use of real human embryos advances individual health and offspring wellbeing and provides essential insights into the components for reproduction and illness.