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Untreated ADHD in Adults Can Lead to Feelings of Worthlessness and Depression Untreated ADHD can lead to chronic underachievement and depression. This is particularly evident when they fail to achieve their professional and personal goals. It are difficult to establish when there are commonalities in symptoms between ADHD and depression. However, identifying the signs is the first step towards receiving treatment. 1. Feelings of Inadequacy Untr