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Taken together, CPUY192018 demonstrates notable effects on counteracting oxidative stress and reprogramming metabolism via Nrf2 activation; hence, being a raising potential therapeutic approach against COPD.Methicillin-resistant Staphylococcus aureus (MRSA) is the leading cause of bacterial pneumonia, featured with exuberant inflammatory cytokine production, extensive oxidative stress and tissue injury. The Keap1/Nrf2 system is the major apparatus essential for host defense against oxidative and electrophilic stresses of both exogenous a