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BACKGROUDS Cannabinoid receptor antagonists happen suggested as a novel treatment for obesity and diabetes. We have created a synthetic cannabinoid receptor antagonist denominated BAR-1. Once the function and integrity of a β-cell mobile framework are essential keys for diabetes onset, we evaluated the effects of pharmacological administration of BAR-1 on prediabetic and diabetic rats. METHODS CD-1 mice fed a hypercaloric diet or treated with streptozoto
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