https://www.selleckchem.com/pr....oducts/sabutoclax.ht
Experiments using a protease-dead IRAP mutant and pharmacological IRAP inhibition suggest that IRAP expression but not proteolytic activity is required for the formation of storage endosomes and for DC-typical phagosome maturation, whereas proteolysis is required for fully efficient cross-presentation. These findings identify IRAP as a key factor in cross-presentation, trimming peptides to fit the major histocompatibility complex class-I binding site while preventing their destruction through premature phagosome maturation.Non-small

https://notes.io/w2LZF
How to Save Money on Audi Battery Replacement Does your Audi key fob experience difficulty locking and unlocking? This could be a sign the battery is in need of replacement. To replace the battery, turn off the metal key and use a flathead screwdriver to pop up the back cover. Insert a new CR1620 and then snap the shell back into the correct position. Low Rate Locksmith It's not common for the batteries in key fobs to go out of service or wear out over the course of time and cause the device to stop working. However, can be fixed with a professional locksmith, wh