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These results demonstrate that continuous exposure of HepaRG cells to a noncytotoxic concentration of NaAsO2 results in substantial epigenetic abnormalities accompanied by several carcinogenesis-related events, including induction of epithelial-to-mesenchymal transition, damage to DNA, inhibition of DNA repair genes, and induction of de novo mutations. Importantly, this study highlights the intimate mechanistic link and interplay between two fundamental cancer-associated events, epigenetic and genetic alterations, in arsenic-associated

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This article explores ways in which the attitudes of the biblical Job may enrich postmodernist philosophy by addressing some of its inherent problems. The discussion focuses in particular on the biblical Book of Job that can serve as an example of confronting suffering as a dramatic implication of human life that denies the sense of happiness. In an attempt to suppress this fear, the postmodern human contests, in various ways, the truth of their ontic frailty and the fragility of their constructed "happiness". The question