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RESULTS All mechanisms are successfully coordinated to mimic the infant feeding mechanism. Suckling frequency and pressure values on the breast phantom from the experimental apparatus are in good agreement with the clinical data. The change in nipple deformation captured by BIBS matches with those from in vivo clinical ultrasound images. SIGNIFICANCE The fully-developed breastfeeding simulator provides a powerful tool for understanding the bio-mechanics of breastfeeding and a foundation for future breastfeeding device development.OBJECTIVE In minimally inva

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The current study aimed to explore the expression of transient receptor potential A1 ion channels (TRPA1) in the rat ureter and to assess if TRPA1-active compounds modulate ureter function. The expression of TRPA1 in rat ureter tissue was studied by immunofluorescence. The TRPA1 distribution was compared to calcitonin gene-related peptide (CGRP), α-actin (SMA1), anoctamin-1 (ANO1), and c-kit. For in vivo analyses, a catheter was implanted in the right ureter of 50 rats. Ureter peristalsis and pressures were continuously recorded by a d