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In the subgranular zone, neurogenesis was induced by exercise in both genotypes, but unaffected by lactate treatment. Our study demonstrates that neurogenesis in the two main neurogenic niches in the brain is regulated differently Neurogenesis in both niches was induced by exercise, but only in the ventricular-subventricular zone was neurogenesis induced by lactate through HCA activation. This opens for a role of HCA in the physiological control of neurogenesis, and potentially in counteractingage-related cognitive decline. Our study demon
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