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nasopharyngeal disease (NPC) is considered the most typical type of head and throat disease in Indonesia (28.4%). Reports indicated that 18.9percent of instances was included with advanced stage. Chemotherapy play crucial role in advanced level phase. Nonetheless, clients with the same phase for the illness might have various treatment response, most likely as a result of the different tumefaction biological qualities. Cyclin D1 is a protein mixed up in