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Getting rid of the Mxra8 insertion in Bovinae enhances alphavirus binding and disease, while introducing the insertion into mouse Mxra8 obstructs CHIKV binding, prevents infection by numerous alphaviruses in cells, and mitigates CHIKV-induced pathogenesis in mice. Our studies on how this insertion provides weight to CHIKV infection could facilitate countermeasures that disrupt Mxra8 communications with alphaviruses. Fecal IgA production depends o

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