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infection. This event may in turn drive the development and exacerbation of chronic airway inflammatory diseases. Our results suggest that the impairments of ciliogenesis and ciliary function in hNECs may be triggered by specific expression of host antiviral response genes during re-epithelization of the nasal epithelium following viral infection. This event may in turn drive the development and exacerbation of chronic airway inflammatory diseases.One of the major reasons why depressed patients fail their treatment course is the existence of the blood-brain