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73 [120.91-411.31] pg/ml, median [IQR]) was higher than in the remission group (40.31 [19.54-151.05] pg/ml, median [IQR]) and HCs group (7.70 [6.13-9.78] pg/ml, median [IQR]) (p less then 0.05). The level of NfL in the remission phase group was higher than in HCs group (p less then 0.05). A negative correlation was found between the serum NfL level and MMSE (p = 0.006, r = -0.65. The NfL concentration correlated positively with stroke-like lesion volume in the brain (r = 0.740, p less then 0.001). Serum NfL may serve as a novel