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Objective to research the practical value and molecular mechanism of endothelial miR-15a/16-1 group on angiogenesis in the ischemic mind. Practices and Results Endothelial cell -selective miR-15a/16-1 conditional knockout (EC-miR-15a/16-1 cKO) mice and WT littermate controls had been subjected to 1h center cerebral artery occlusion (MCAO) followed by 28d reperfusion. Deletion of miR-15a/16-1 group in endothelium attenuates post-stroke brain infarction and atrophy, and gets better the long-lasting sensorimotor and