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The purpose of our study was to compare the cost of surgical site skin preparation using ChloraPrep™ (2% chlorhexidine gluconate [CHG] and 70% isopropyl alcohol [IPA]) with skin cleansing using Betadine® Surgical Scrub and Betadine® 5% solution (povidone-iodine [PVI]) in total hip arthroplasty (THA). The hypothesis was that the ChloraPrep™ skin disinfection protocol reduces the cost of perioperative antisepsis. A prospective database was created for all THAs performed at our university hospital between November1st, 2020, and December31st