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RESULTS In this study, COX-2 considered as the potential target for Hepatocellular Carcinoma which was examined with Tangeretin. CONCLUSION Tangeretin was screened against C0X-2 which includes Molecular Docking, DFT analysis, ADMET prediction, and Molecular Dynamics simulation. Tangeretin had good docking scores, fulfill the pharmacological properties through ADMET prediction, and the Protein-Ligand complex had good stability in Molecular Dynamics simulation. Copyright© Bentham Science Publishers; For any queries, please email at epub@