https://telaprevirinhibitor.co....m/overdue-pulmonary-
Here, we show that olrn-1 also works in AWC neurons in the cell non-autonomous suppression associated with the canonical p38 MAPK PMK-1 immune path in the intestine. Minimal activity of OLRN-1, which triggers the p38 MAPK signaling cassette in AWC neurons during larval development, also de-represses the p38 MAPK PMK-1 pathway in the bowel to promote protected effector transcription, increased clearance of an intestinal pathogen, and weight to infection. These