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We applied immunohistochemistry with antibodies to real human CD63 on 620 successive CRC patients addressed in the Helsinki University Hospital. We evaluated the organizations between CD63 appearance and clinicopathological variables and patient prognosis. We found that CD63 expression associated with a sophisticated stage, bad differentiation, and mucinous histology. We discovered no association between CD63 appearance and age, sex or tumefaction location. CD63 phrase predicted an unfavorable progn